1887

Abstract

SUMMARY

Vero cells were persistently infected with canine distemper virus by continuous undiluted passage of virus harvests. The cells were refractory to superinfection by both measles virus and canine distemper virus. These persistently infected cells produced and released into the medium a labile component which had a potent and selective inhibitory effect on the replication of canine distemper and measles virus. The inhibitory agent was not inactivated by u.v.-irradiation or sedimented by ultracentrifugation. Antisera against canine distemper virus or SSPE sera were able to block this inhibitory effect. We propose that these persistently infected cells produce an excess of a virus-induced regulatory protein.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-32-3-431
1976-09-01
2022-10-04
Loading full text...

Full text loading...

/deliver/fulltext/jgv/32/3/JV0320030431.html?itemId=/content/journal/jgv/10.1099/0022-1317-32-3-431&mimeType=html&fmt=ahah

References

  1. APPEL M., ROBSON D. S. 1973; A microneutralization test for canine distemper virus. American Journal of Veterinary Research 34:1459–1463
    [Google Scholar]
  2. COLE F. E., HETRICH F. M. 1965; Persistent infection of human conjunctiva cell cultures by myxovirus parainfluenza 3. Canadian Journal of Microbiology 11:513–514
    [Google Scholar]
  3. FERNANDES M. V., WIKTOR T. J., KOPROWSKI H. 1964; Endosymbiotic relationship between animal viruses and host cells. A study of rabies virus in tissue culture. Journal of Experimental Medicine 120:1099–1116
    [Google Scholar]
  4. FUCCILLO D., KURENT J. E., SEVER J. L. 1974; Slow virus diseases. Annual Review of Microbiology 28:231–264
    [Google Scholar]
  5. HALL W. W., MARTIN S. J., GOULD D. A. 1974; Defective interfering particles produced during the replication of measles virus. Medical Microbiology and Immunology 160:155–164
    [Google Scholar]
  6. HOLLAND J.J., VILLARREAL L. P. 1974; Persistent non-cytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase. Proceedings of the National Academy of Sciences of the United States of America 71:2956–2960
    [Google Scholar]
  7. HUANG A. S., BALTIMORE D. 1970; Defective viral particles and viral disease processes. Nature, London 226:325–327
    [Google Scholar]
  8. LINCOLN S. D., GORHAM J. R., OTT R. L., HEGREBERG G. A. 1971; Etiologic studies on old dog encephalitis. Veterinary Pathology 8:1–8
    [Google Scholar]
  9. LOCKART R. Z. 1960; The production and maintenance of a virus carrier state; the possible role of homologous interference. Virology 10:198–210
    [Google Scholar]
  10. TER MEULEN V., KATZ M., KÂCKELL Y. M., BARBANTI-BRODANO G., KOPROWSKI H., LENNETTE E. H. 1972; SSPE: [i]in vitro[/i] characterization of viruses isolated from brain cell in culture. Journal of Infectious Diseases 126:11–17
    [Google Scholar]
  11. PREBLE O. T., YOUNGNER J. S. 1975; Temperature-sensitive mutant viruses and the etiology of chronic and inapparent infections. Journal of Infectious Diseases 131:467–473
    [Google Scholar]
  12. RODRIGUEZ J. E., HENLE W. 1965; Studies on persistent infections of tissue cultures. V. The initial stages of infection of L (MCN) cells by Newcastle disease virus. Journal of Experimental Medicine 119:895–922
    [Google Scholar]
  13. RUSTIGIAN R. 1966; Persistent infection of cells in culture by measles virus. I. Development and characteristics of HeLa sublines persistently infected with complete virus. Journal of Bacteriology 92:1792–1804
    [Google Scholar]
  14. WALKER D. L., HINZE H. C. 1962; A carrier state of mumps virus in human conjuctiva cells. I. General characteristics. Journal of Experimental Medicine 116:739–750
    [Google Scholar]
  15. WIKTOR T. J., CLARK H. F. 1972; Chronic rabies virus infection of cell cultures. Infection and Immunity 6:988–995
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-32-3-431
Loading
/content/journal/jgv/10.1099/0022-1317-32-3-431
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error