1887

Abstract

SUMMARY

The surface nature of the proteins of a bovine enterovirus have been determined by using I and pyridoxal phosphate-sodium borohydride labelling techniques. As found previously, I labels only VP in intact capsid particles, whereas reaction with pyridoxal phosphate followed by reduction with tritiated sodium borohydride labels VP, VP and VP. Only VP is found to have no surface tyrosine, histidine or lysine available for reaction. After neutralization with homologous antisera, however, VP becomes exposed and is then available for labelling with I. This must reflect a substantial conformational change in the virus particle after neutralization.

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/content/journal/jgv/10.1099/0022-1317-32-1-17
1976-07-01
2022-01-28
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