Interferon Production in Athymic Nude Mice Free

Abstract

SUMMARY

Athymic (homozygous nude) mice of a non-inbred stock had relatively little antiviral activity in their serum compared with normal control mice at 4, 6 and 6.5 h after the intraperitoneal injection of Newcastle disease virus. The antiviral activity in the serum had the characteristics of interferon. At 10 h after injection and thereafter, the serum titres were comparable in nude and normal control mice. Exceptional nude mice with thymus-like tissue sometimes produced interferon more or less normally. Transfer of spleen cells from normal donor mice, but not from nude donors, led to increased serum interferon levels in nude recipient mice at 4 h after virus injection.

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/content/journal/jgv/10.1099/0022-1317-32-1-149
1976-07-01
2024-03-28
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References

  1. EPSTEIN L. B., AMMAN A. L. 1974; Evaluation of T lymphocyte effector function in immunodeficiency diseases: abnormality in mitogen-stimulated interferon in patients with selective IgA deficiency. Journal of Immunology 112:617–626
    [Google Scholar]
  2. LAIR S. V., BROWN A., LOZZIO B. B. 1974; Induction of interferon in hereditarily asplenic mice with and without a neonatal spleen cell transplant. Proceedings of the Society for Experimental Biology and Medicine 146:475–477
    [Google Scholar]
  3. MAEHARA V., NAGANO Y. 1972; Formation of virus inhibitory factor or interferon in splenectomised mice. Japanese Journal of Microbiology 16:469–474
    [Google Scholar]
  4. DE MAEVER-GUIGNARD J., DE MAEYER R. 1971; Effect of antilymphocyte serum on circulating interferon in mice as a function of the inducer. Nature New Biology 229:221–214
    [Google Scholar]
  5. PANTELOURIS E. M. 1968; Absence of thymus in a mouse mutant. Nature, London 217:370–371
    [Google Scholar]
  6. PANTELOURIS E. M. 1975; Nude mice with normal thymus. Nature, London 254:140–141
    [Google Scholar]
  7. PANTELOURIS E. M., HAIR J. 1970; Thymus dysgenesis in nude ([i]nunu[/i]) mice. Journal of Embryology and Experimental Morphology 24:615–623
    [Google Scholar]
  8. STOBO J-, GREEN I., IACKSON L., BARON S. 1974; Identification of a subpopulation of mouse lymphoid cells required for interferon production after stimulation with mitogens. Journal of Immunology 112:1589–1593
    [Google Scholar]
  9. WOODRUFF J. F., KILBOURNE E. D. 1967; Interferon production in neonatally thymectomised mice. Proceedings of the Society for Experimental Biology and Medicine 126:542–548
    [Google Scholar]
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