1887

Abstract

SUMMARY

Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV). This suppression was maximal when cells were treated with retinoic acid for 2 h after NDV adsorption, indicating that the inhibitory step was an early event. It was not due to inhibition of total RNA synthesis. Retinoic acid treatment caused both a delay in appearance of interferon and a reduced rate of synthesis thereafter.

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/content/journal/jgv/10.1099/0022-1317-32-1-143
1976-07-01
2021-10-16
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References

  1. BLALOCK J. E., GIFFORD G. E. 1974; Effect of Aquasol A, vitamin A and Tween 80 on vesicular stomatitis virus plaque formation and on interferon action. Archiv für die Gesamte Virusforschung 45:161–164
    [Google Scholar]
  2. BLALOCK J. E., GIFFORD G. E. 1975; Inhibition of interferon action by vitamin A. Journal of General Virolo-ogy 29:314–324
    [Google Scholar]
  3. BUCHAN A., BURKE D. C. 1966; Interferon production in chick embryo cells. The effect of puromycin and p-fluorophenylalanine. Biochemical Journal 98:530–536
    [Google Scholar]
  4. DELUCA L., YUSPA S. H. 1974; Altered glycoprotein synthesis in mouse epidermal cells treated with retinyl acetate [i]in vitro[/i]. Experimental Cell Research 86:106–110
    [Google Scholar]
  5. DORNER F., SCRIBA M., WEIL R. 1973; Interferon: evidence for glycoprotein nature. Proceedings of the National Academy of Sciences of the United States of America 70:1981–1985
    [Google Scholar]
  6. GOOHRA R. M., GIFFORD G. E. 1971; Comparison of interferon induction by active and inactive Semliki Forest virus. Journal of General Virology 10:117–124
    [Google Scholar]
  7. HO M., BREINIG M. K. 1965; Metabolic determinants of interferon formation. Virology 25:331–339
    [Google Scholar]
  8. KRONENBERG L. H., FRIEDMAN T. 1975; Relative quantitative assay of the biological activity of interferon messenger ribonucleic acid. Journal of General Virology 27:225–238
    [Google Scholar]
  9. LEVY H. B., AXELROD D., BARON S. 1965; Messenger RNA for interferon production. Proceedings of the Society for Experimental Biology and Medicine 118:384–385
    [Google Scholar]
  10. TOKUMARU T. 1967; The effect of trauma on production of herpes interferon in guinea pigs. Archiv für die Gesamte Virusforschung 21:61–70
    [Google Scholar]
  11. WAGNER R. R., HUANG A. S. 1965; Reversible inhibition of interferon synthesis by puromycin. Evidence for an interferon-specific messenger RNA. Proceedings of the National Academy of Sciences of the United States of America 54:1112–1118
    [Google Scholar]
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