1887

Abstract

SUMMARY

Using 5′-nucleotidase and NADPH:cytochrome c reductase as respective enzyme markers for the plasma membrane and endoplasmic reticulum, a satisfactory separation of these two membrane fractions from a cell line (SMB) derived from a scrapie mouse brain has been achieved. The coincident distribution of scrapie infectivity and 5′-nucleotidase in various fractions isolated from these cells indicates that most of the scrapie infectivity present in this cell line is associated with the plasma membrane.

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/content/journal/jgv/10.1099/0022-1317-31-3-441
1976-06-01
2021-10-28
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