@article{mbs:/content/journal/jgv/10.1099/0022-1317-31-3-429, author = "Allen, P. T. and Schellekens, H. and Van Griensven, L. J. L. D. and Billiau, A.", title = "Differential Sensitivity of Rauscher Murine Leukaemia Virus (MuLV-R) to Interferons in Two Interferon-Responsive Cell Lines", journal= "Journal of General Virology", year = "1976", volume = "31", number = "3", pages = "429-435", doi = "https://doi.org/10.1099/0022-1317-31-3-429", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-31-3-429", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY The effect of interferon on the replication of vesicular stomatitis virus (VSV) and type-C oncornavirus in two Balb/c mouse cell lines, JLS-V5 and JLS-V9R, infected with MuLV-R was examined. VSV replication was inhibited threefold (0·5 log10) in both cell lines by 10 to 20 units of interferon/ml. In JLS-V5 cells C-type virus yields, as measured by 3H-uridine incorporation and reverse transcriptase activity, were also reduced three-fold by 10 to 20 units of interferon/ml. However, in JLS-V9R cells, C-type virus replication was refractory to interferon at concentrations up to 1 × 104 units/ml. Infectious C-type virus transmitted from JLS-V9R cells to Balb/3T3 cells was as sensitive to interferon as virus transmitted from JLS-V5 cells, indicating that resistance of C-type virus in JLS-V9R cells is a feature of the cells rather than of the virus strain.", }