1887

Abstract

Summary

Three mutants of herpes simplex virus (HSV) have been isolated which form plaques in the presence of 100 µg/ml phosphonacetic acid (PPA). All three mutants (3 from HSV-1 strain 17 , from HSV-1 strain 17 , and 19 from HSV-2) induce viral DNA synthesis and viral DNA polymerase activity, and these are much less sensitive to PPA than the wild-type virus. The results support the hypothesis that PPA interacts directly with the viral DNA polymerase protein, at least part of which is virus coded.

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/content/journal/jgv/10.1099/0022-1317-31-1-145
1976-04-01
2019-10-18
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-31-1-145
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