@article{mbs:/content/journal/jgv/10.1099/0022-1317-30-3-347, author = "Grose, C. and Horwitz, M. S.", title = "Characterization of an Enterovirus Associated with Acute Infectious Lymphocytosis", journal= "Journal of General Virology", year = "1976", volume = "30", number = "3", pages = "347-355", doi = "https://doi.org/10.1099/0022-1317-30-3-347", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-30-3-347", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY An enterovirus (EVU-16) previously isolated from children with acute infectious lymphocytosis has been further characterized. The EVU-16 virus sediments as a 135S particle in sucrose gradients, has a density of 1.335 g/ml in CsCl, contains 4 polypeptides and has a single stranded RNA genome sedimenting at 35S. These structural features as well as the presence of a virus-related particle, the procapsid, are similar to those of other enteroviruses. However, the largest polypeptide of EVU-16 is 49 000 daltons, which is considerably larger than the corresponding polypeptide from poliovirus; the sizes of the other three viral polypeptides were similar in both viruses. Attempts to induce lymphocytosis by the inoculation of EVU-16 into various animals, including immunologically aberrant ‘nude’ mice, were unsuccessful.", }