Thirteen mutants of type 2 herpes simplex virus were backcrossed to a syncytial but not temperature-sensitive mutant of wild-type virus. This was an attempt to introduce a third marker, syncytial plaque morphology or , into at least some of the mutants. Three mutants carrying the marker were obtained but only one, 9, was satisfactory for genetic experiments. Three-factor crosses were carried out between 9 and the mutants which determined the order of eleven mutations relative to both the 9 mutation and the mutation. A provisional linkage map based both on the order derived from the three-factor crosses and on map distances from recombination frequencies has been prepared: it contains nine mutations and the mutation.


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