One of the ‘early’ effects of cellular infection by DNA-containing viruses is an increase of various enzymic activities concerned in DNA synthesis, which in most instances seems dependent upon the synthesis of virus-coded enzymes (Keir, 1968).

As far as poxviruses are concerned, relevant information relates almost exclusively to the vaccinia subgroup and very little is known about other poxviruses (Joklik, 1966).

The Shope fibroma virus is an oncogenic pox virus of the myxoma subgroup (Joklik, 1966) and has only recently been subjected to systematic study in tissue cultures. It has been shown to replicate in primary cell cultures of human amnion (Hodes 1966; La Placa 1967; Hodes & Chang, 1968) where it causes a peculiar cytopathic effect characterized by the appearance of pock-like lesions (La Placa 1967). The time-course of nucleic acid synthesis (Ewton & Hodes, 1967) and the induction of DNA nucleotidyltransferase (Chang & Hodes, 1967) in cells infected with Shope fibroma virus have also been reported.


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