Interferon Induction by Viruses and Polynucleotides: A Differential Effect of Camptothecin Free

Abstract

Summary

The plant alkaloid camptothecin inhibits interferon production induced by Newcastle disease virus (NDV) or ultraviolet-irradiated NDV in chick and human cells, and by Sindbis virus in chick cells. It has no effect on interferon production induced by poly(rI).poly(rC) in chick and human cells. No effect of camptothecin could be detected on the multiplication of NDV, and it is concluded that the inhibition reflects a difference between interferon induction by viruses and by polynucleotides.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-29-3-297
1975-12-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/29/3/JV0290030297.html?itemId=/content/journal/jgv/10.1099/0022-1317-29-3-297&mimeType=html&fmt=ahah

References

  1. Abelson H., Penman S. 1972; Selective interruption of high molecular weight RNA synthesis in HeLa cells by camptothecin. Nature New Biology 237:144–146
    [Google Scholar]
  2. Atkins G. J., Johnston M. D., Westmacott L. M., Burke D. C. 1974; Induction of interferon in chick cells by temperature-sensitive mutants of Sindbis virus. Journal of General Virology 25:381–390
    [Google Scholar]
  3. Bausek G. H., Merigan T. C. 1970; Simultaneous viral and non-viral interferon production in human cell cultures. Proceedings of the Society for Experimental Biology and Medicine 133:982–985
    [Google Scholar]
  4. Bosmann H. B. 1970; Camptothecin inhibits macromolecular synthesis in mammalian cells but not in isolated mitochondria or E. coli. Biochemical and Biophysical Research Communications 41:1412–1420
    [Google Scholar]
  5. Burke D. C. 1973; The mechanism of interferon formation. In Interferon and Interferon Inducers pp 107–133 Edited by Finter N. B. New York: Elsevier Publishing Company;
    [Google Scholar]
  6. Colby C., Chamberlain M. J. 1969; The specificity of interferon induction in chick embryo cells by helical RNA. Proceedings of the National Academy of Sciences of the United States of America 63:160–167
    [Google Scholar]
  7. Colby C., Duesberg P. H. 1969; Double-stranded RNA in vaccinia virus infected cells. Nature, London 222:940–944
    [Google Scholar]
  8. De Clercq E., Merigan T. C. 1969; Requirement of a stable secondary structure for the antiviral activity of polynucleotides. Nature, London 222:1148–1152
    [Google Scholar]
  9. De Maeyer E., De Maeyer-Glfignard J., Hall W. T., Bailey D. W. 1974; A Locus affecting circulating interferon levels induced by mouse mammary tumour virus. Journal of General Virology 23:209–211
    [Google Scholar]
  10. Huang J. W., Davey M. W., Hejna C. J., Van Muenchhausen W., Sulkowski E., Carter W. A. 1974; Selective binding of human interferon to albumin immobilised on agarose. Journal of Biological Chemistry 249:4665–4667
    [Google Scholar]
  11. Huppert J., Hillova J., gresland L. 1969; Viral RNA synthesis in chicken cells infected with ultraviolet irradiated Newcastle disease virus. Nature, London 223:1015–1017
    [Google Scholar]
  12. Kessel D., Dysard R. 1973; Effects of camptothecin on RNA synthesis in L1210 cells. Biochimica et Biophysica Acta 312:716–721
    [Google Scholar]
  13. Levine E. M. 1972; Mycoplasma contamination of animal cell cultures: a simple, rapid detection method. Experimental Cell Research 74:99–109
    [Google Scholar]
  14. Mcwilliam M., Finkelstein M. S., Allen P. T., Giron D. J. 1971; Assay of chick interferon by the inhibition of viral ribonucleic acid synthesis. Applied Microbiology 21:959–961
    [Google Scholar]
  15. Meager A., Burke D. C. 1972; Production of interferon by ultraviolet radiation inactivated Newcastle disease virus. Nature, London 235:280–282
    [Google Scholar]
  16. Morser M. J., Kennedy S. I. T., Burke D. C. 1973; Virus-specified polypeptides in cells infected with Semliki Forest virus. Journal of General Virology 21:19–30
    [Google Scholar]
  17. Oravec M., Kumar A., Wu R. S. 1972; Inhibition of labelling of messenger and nucleoplasmic RNA of HeLa cells by camptothecin. Biochimica et Biophysica Acta 272:607–611
    [Google Scholar]
  18. Russell W. C., Newman C., Williamson D. H. 1975; A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses. Nature, London 253:461–462
    [Google Scholar]
  19. Stewart W. E., Gosser L. B., Lockart R. Z. 1971; Distinguishing characteristics of the interferon responses of primary and continuous mouse cell cultures. Journal of General Virology 13:35–50
    [Google Scholar]
  20. Vilček J., Ng M. H., Friedman-Kein A. E., Krawciw T. 1968; Induction of interferon synthesis by synthetic double-stranded polynucleotides. Journal of Virology 2:648–650
    [Google Scholar]
  21. Wall M. E., Wani M. C., Cook C. E., Palmer K. H., Mcphail A. J., Sun G. A. 1966; Plant antitumour agents. I. The isolation and structure of camptothecin, a novel alkaloid and leukemia and tumour inhibitor from camptotheca accuminata. Journal of the American Chemical Society 88:3888–3890
    [Google Scholar]
  22. Wu R. S., Kumar A., Warner J. R. 1971; Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proceedings of the National Academy of Sciences of the United States of America 68:3009–3014
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-29-3-297
Loading
/content/journal/jgv/10.1099/0022-1317-29-3-297
Loading

Data & Media loading...

Most cited Most Cited RSS feed