1887

Abstract

Summary

Rubella virus was isolated from the brain of a congenitally-infected, 12-year-old child in whom progressive mental and motor deterioration became evident at age 8 and 11 years respectively. The virus was initially isolated in a co-culture of CV-1 cells with the trypsinized brain tissue; subsequently the culture of the brain tissue also showed evidence of rubella virus infection recognized by indirect fluorescent antibody technique (IFA) using anti-rubella virus antibody prepared in rabbits as intermediate serum. Both isolates interfered with infection of BSC-1 cell lines by echovirus type 11. The interfering virus was identified as rubella virus by IFA with the specific antiserum, and it is designated as the NTr strain of rubella virus. The complement fixing antibody titre to rubella virus in serum was 1:256. The spinal fluid was anticomplementary. Rubella virus haemagglutinating antibody titre (HI) in serum was 1:8196 and in the spinal fluid 1:128. The HI antibody was of the IgG class. The corresponding HI titres to rubeola virus in serum and spinal fluid were 1:8 and < 1:2 respectively.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-29-2-143
1975-11-01
2019-12-09
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-29-2-143
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error