@article{mbs:/content/journal/jgv/10.1099/0022-1317-28-3-409, author = "Oxford, J. S.", title = "Inhibition of the Replication of Influenza A and B Viruses by a Nucleoside Analogue (Ribavirin)", journal= "Journal of General Virology", year = "1975", volume = "28", number = "3", pages = "409-414", doi = "https://doi.org/10.1099/0022-1317-28-3-409", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-28-3-409", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Summary A synthetic nucleoside analogue 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin or RTCA) inhibits the replication in tissue culture of influenza B virus and also a wide range of influenza A viruses of human, animal and avian origin. The synthesis of influenza virus-induced antigens and also structural and non-structural polypeptides is inhibited by RTCA as detected by immunofluorescence and by pulse labelling experiments with [35S]-methionine. The inhibitory effects of RTCA on influenza A virus replication in tissue culture is reversed by a molar excess of guanosine or xanthosine which suggests that the compound acts at an early stage of virus RNA synthesis prior to the utilisation of the latter nucleosides. A possible inhibitory effect of RTCA on cellular DNA replication is not excluded.", }