Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease Free

Abstract

Summary

Nineteen recent isolates and three laboratory strains of herpes simplex virus types 1 and 2 were tested for their ability to produce clinical signs in mice following intradermal inoculation in the ear. All viruses produced erythema at the inoculation site; this was the most sensitive clinical sign of infection. Virus multiplication in the ear tissue was similar for both types 1 and 2 up to the fifth day after inoculation but type 2 viruses persisted for longer. Latent infection was demonstrated in cervical dorsal root ganglia. Type 1 viruses required a much higher dose than type 2 to produce neurological signs and death after intradermal inoculation but the difference was less after intracerebral inoculation.

Erythema of the inoculated ear recurred sporadically during several months observation in about half the mice that survived intradermal infection with a selected type 1 isolate. The presence of virus in the ear tissue during such recurrences was confirmed by electron microscopy and isolation of infectious virus. The system of ear infection in the mouse is presented as a new model for studying neurovirulence, and latent and recurrent infection with herpes simplex virus.

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1975-09-01
2024-03-28
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References

  1. Anderson W. A., Magruder B., Kilbourne E. D. 1961; Induced reactivation of herpes simplex virus in healed rabbit corneal lesions. Proceedings of the Society for Experimental Biology and Medicine 107:628–631
    [Google Scholar]
  2. Baringer J. R. 1974; Herpes simplex virus in human sacral ganglia. New England Journal of Medicine 291:828–830
    [Google Scholar]
  3. Baringer J. R., Swoveland P. 1973; Recovery of herpes simplex virus from human trigeminal ganglia. New England Journal of Medicine 288:648–650
    [Google Scholar]
  4. Bastian F. O., Rabson A. S., Yee C. L., Tralka T. S. 1972; Herpesvirus hominis: isolation from human trigeminal ganglion. Science, New York 178:306–307
    [Google Scholar]
  5. Becker C. H. 1968; Die multiplikation des Aujeszkyshen virus in den spinal ganglien des kanichens. Archiv fur experimented Veterinarmedizin 22:363–381
    [Google Scholar]
  6. Bradish C. J., Allner K., Maber H. B. 1972; Infection, interaction and the expression of virulence by defined strains of Semliki Forest virus. Journal of General Virology 16:359–372
    [Google Scholar]
  7. Cook M. L., Stevens J. G. 1973; Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infection and Immunity 7:272–288
    [Google Scholar]
  8. Dillard S. H., Cheatham W. J., Moses H. L. 1972; Electron microscopy of zosteriform herpes simplex infection in the mouse. Laboratory Investigation 26:391–402
    [Google Scholar]
  9. Field H. J., Hill T. J. 1974; The pathogenesis of pseudorabies in mice following peripheral inoculation. Journal of General Virology 23:145–157
    [Google Scholar]
  10. Field H. J., Hill T. J. 1975; The pathogenesis of pseudorabies in mice: virus replication at the inoculation site and axonal uptake. Journal of General Virology 26:145–148
    [Google Scholar]
  11. Figueroa M. E., Rawls W. E. 1969; Biological markers for differentiation of herpesvirus strains of oral and genital origin. Journal of General Virology 4:259–267
    [Google Scholar]
  12. Finney D. J. 1952 In Statistical Methods in Biological Assay pp 524–530 London: Griffin;
    [Google Scholar]
  13. Good R. A., Campbell B. 1948; The precipitation of latent herpes simplex encephalitis by anaphylactic shock. Proceedings of the Society for Experimental Biology and Medicine 68:82–87
    [Google Scholar]
  14. Hill T. J., Field H. J. 1973; The interaction of herpes simplex virus with cultures of peripheral nervous tissue: an electron microscopic study. Journal of General Virology 21:123–133
    [Google Scholar]
  15. Hirsch M. S., Zisman B., Allison A. C. 1970; Macrophages and age dependent resistance to herpes simplex in mice. Journal of Immunology 104:1160–1165
    [Google Scholar]
  16. Kristensson K., Olsson Y. 1973; Diffusion pathways and retrograde axonal transport of protein tracers in peripheral nerves. Progress in Neurobiology 11:87–104
    [Google Scholar]
  17. Laibson P. R., Kibrick S. 1966; Reactivation of herpetic keratitis by epinephrine in the rabbit. Archives of Ophthalmology 75:254–260
    [Google Scholar]
  18. Mccracken R. M., Mcferran J. B., Dow C. 1973; The neural spread of pseudorabies virus in calves. Journal of General Virology 20:17–28
    [Google Scholar]
  19. Mckendall R. R., Vogelzang N., Jackson G. G. 1974; Herpesvirus latency in spinal ganglia of mice without illness. Proceedings of the Society for Experimental Biology and Medicine 146:1093–1096
    [Google Scholar]
  20. Murphy F. A., Harrison A. K., Winn W. C., Bauer J. P. 1973; Comparative pathogenesis of rabies and rabies-like viruses: infection of the central nervous system and centrifugal spread of virus to peripheral tissues. Laboratory Investigation 29:1–16
    [Google Scholar]
  21. Nahmias A. J., Dowdle W. R. 1968; Antigenic and biological differences in herpesvirus hominis. Progress in Medical Virology io:110–159
    [Google Scholar]
  22. Plummer G., Waner J. L., Phuangsab A., Goodheart C. R. 1970; Type i and type 2 herpes simplex viruses: serological and biological differences. Journal of Virology 5:51–59
    [Google Scholar]
  23. Rodda S., Jack L., White D. O. 1973; Herpes simplex virus from trigeminal ganglion. Lancet 1:1395
    [Google Scholar]
  24. Schmidt J. R., Rasmussen A. F. 1960; Activation of latent herpes simplex encephalitis by chemical means. Journal of Infectious Diseases 106:154–158
    [Google Scholar]
  25. Schwartz J., Roizman B. 1969; Similarities and differences in the development of laboratory strains and freshly isolated strains of herpes simplex virus in HEp-2 cells: electron microscopy. Journal of Virology 4:879–899
    [Google Scholar]
  26. Stevens J. A., Cook M. L. 1971; Latent herpes simplex virus in spinal ganglia of mice. Science, New York 173:843–845
    [Google Scholar]
  27. Stevens J. G., Cook M. L. 1973; Latent herpes simplex infection. In Virus Research pp 437–446 Edited by Fox C. F., Robinson W. S. New York: Academic Press;
    [Google Scholar]
  28. Underwood G. E., Weed S. D. 1974; Recurrent cutaneous herpes simplex in hairless mice. Infection and Immunity 10:471–474
    [Google Scholar]
  29. Walz M. A., Price R. W., Notkins A. L. 1974; Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science, New York 184:1185–1187
    [Google Scholar]
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