RT Journal Article SR Electronic(1) A1 Lonberg-Holm, K.YR 1975 T1 The Effects of Concanavalin A on the Early Events of Infection by Rhinovirus Type 2 and Poliovirus Type 2 JF Journal of General Virology, VO 28 IS 3 SP 313 OP 327 DO https://doi.org/10.1099/0022-1317-28-3-313 PB Microbiology Society, SN 1465-2099, AB Summary The effect of concanavalin A (Con A) on the course of early infection of HeLa cells with purified radioactive human rhinovirus type 2 (HRV-2) or poliovirus type 2 (P-2) has been examined. Several early steps in infection were inhibited before the uncoating of parental virus. Con A, at 100 µg/ml, reduces attachment of virus when added to cells before infection. Con A also detectably slows the normal progression of adsorbed virus to tightly bound forms characterized, in the case of HRV-2, by resistance to elution by EDTA, or in the case of P-2, by isolation of a characteristic virus-membrane complex. When Con A is added together with either virus, it also inhibits cell-mediated eclipse of infectivity and the formation of non-infective subviral particles., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-28-3-313