Immunomodification and the Expression of Virulence in Mice by Defined Strains of Semliki Forest Virus: the Effects of Myocrisin and l-Asparaginase Free

Abstract

SUMMARY

Studies in mice of the modes of immunomodification imposed by cyclophosphamide, have been extended to comparative studies with Myocrisin, l-asparaginase and interferon. It has been shown for mice infected or by an avirulent clone of SFV, that the potentiation of disease may be marked by many distinct changes in the type and rate of response.

For low doses of virus, enhancement (Myocrisin, l-asparaginase) or impairment (interferon) of the efficiency of infection may be associated with death (potentiation by Myocrisin) or protection (immunoenhancement by l-asparaginase).

For higher doses of virus the increased mortality after infection (primary potentiation) is determined within 2 or 3 days and appears to be due to inhibition of phagocytosis (Myocrisin and l-asparaginase) and of T cell functions (l-asparaginase and cyclophosphamide). The increased incidence of death after challenge (secondary potentiation) appears to be due to inhibition of B cell functions (cyclophosphamide) associated with suppression of antibody synthesis and persistence of viraemia.

These results are discussed in relation to the expression of virulence by a heterogeneous and replicating antigen. The critical cellular and humoral changes which occur within 2 or 3 days of infection are emphasized.

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1975-08-01
2024-03-28
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References

  1. Allner K., Bradish C. J., Fitzgeorge R., Nathanson N. 1974; Modifications by sodium auro-thio-malate of the expression of virulence in mice by defined strains of Semliki Forest virus. Journal of General Virology 24:221–228
    [Google Scholar]
  2. Ashworth L. A. E., Maclennan A. P. 1974; Comparison of the 1-asparaginase from Escherichia coli and Erwinia carotovora as immunosuppressants. Cancer Research 34:1353–1359
    [Google Scholar]
  3. Baron S. 1973; The defensive and biological roles of the interferon system. In Interferons and Interferon Inducers 2nd revised edition Edited by Finter N. Amsterdam: North-Holland;
    [Google Scholar]
  4. Berenbaum M. C., Cope W. A., Jeffery W. 1973; Differential asparaginase sensitivity of T-cell and B-cell responses. Clinical and Experimental Immunology 15:565–572
    [Google Scholar]
  5. Bradish C. J., Allner K. 1970; The production of mouse interferon in rolling monolayers of L-cells. Symposia Series in Immunobiological Standardization 1435–36 Basel: Karger;
    [Google Scholar]
  6. Bradish C. J., Allner K. 1972; The early responses of mice to respiratory and intraperitoneal infection by defined virulent and avirulent strains of Semliki Forest virus. Journal of General Virology 15:205–218
    [Google Scholar]
  7. Bradish C. J., Allner K., Fitzgeorge R. 1975; Immunomodification and the expression of virulence in mice by defined strains of Semliki Forest virus. The effects of cyclophosphamide. Journal of General Virology (in the press)
    [Google Scholar]
  8. Bradish C. J., Allner K., Maber H. B. 1971; The virulence of original and derived strains of Semliki Forest virus for mice, guinea-pigs and rabbits. Journal of General Virology 12:141–160
    [Google Scholar]
  9. Cameron K. R., Bradish C. J. 1972; The kinetics of haemagglutination by Semliki Forest virus: a new sedimentation-enumeration method. Journal of General Virology 16:135–152
    [Google Scholar]
  10. Darnell M. B., Koprowski H. 1974; Genetically determined resistance to infection with group B arboviruses. II. Increased production of interfering particles in cell cultures from resistant mice. The Journal of Infectious Diseases 129:248–256
    [Google Scholar]
  11. Davies A. J. S., Carter R. L. 1973; Thymus dependency. In Contemporary Topics in Immunobiology vol 2 New York: Plenum;
    [Google Scholar]
  12. Fantes K. H. 1973; Interferons: purification and properties. In Interferons and Interferon Inducers 2nd revised edition Edited by Finter N. Amsterdam: North-Holland;
    [Google Scholar]
  13. Fitzgeorge R., Bradish C. J. 1973; Immunospecific isolation of antibodies by dissociation from virus or particulate antigen adsorbed on charcoal. Immunochemistry 10:21–29
    [Google Scholar]
  14. Greaves M. F., Owen J. J. T., Raff M. C. 1973; T and B lymphocytes: origins, properties and roles in immune response. Excerpta Medica; Amsterdam:
    [Google Scholar]
  15. Huang A. S. 1973; Defective interfering viruses. Annual Review of Microbiology 27:101–117
    [Google Scholar]
  16. Johnson R. T., Mims C. A. 1968; Pathogenesis of viral infections of the nervous system. New England Journal of Medicine 278:23–30 84–92
    [Google Scholar]
  17. Lashkin A., Lechevalier H. A. 1972; Macrophages and cellular immunity. Chemical Rubber Company Monoscience Series
    [Google Scholar]
  18. Makinodan T., Santos W. W., Quinn R. P. 1970; Immunosuppressive drugs. Pharmacological Reviews 22:189–247
    [Google Scholar]
  19. Murphy F. A., Harrison A. K., Collin W. K. 1970; The role of extraneural arbovirus infections in the pathogenesis of encephalitis. Laboratory Investigations 22:318–328
    [Google Scholar]
  20. Neurath A. R., Rubin B. A. 1971; Viral structural components as immunogens of prophylactic value. In Monographs in Virology 4 Edited by Melnick J. L. Basel: Karger;
    [Google Scholar]
  21. Nelson D. S. 1969 In Macrophages and Immunity Amsterdam: North Holland;
    [Google Scholar]
  22. Pusztai R., Gould E. A., Smith H. 1971; Infection patterns in mice of an avirulent and virulent strain of Semliki Forest virus. British Journal of Experimental Pathology 52:669–677
    [Google Scholar]
  23. Thind I. S., Price W. H. 1968; Passive transfer of acquired resistance in mice to group B arboviruses by serum protective factors independent of serum neutralizing antibody or interferon. American Journal of Epidemiology 88:287–300
    [Google Scholar]
  24. Wade H. E., Rutter D. A. 1970; Asparaginase treatment for leukaemia. Science Journal 6:62–67
    [Google Scholar]
  25. Walder R., Bradish C. J. 1975; Venezuelan equine encephalomyelitis virus: strain differentiation and the specification of virulence markers. Journal of General Virology (in the press)
    [Google Scholar]
  26. Wheelock E. E., Toy S. T. 1973; Participation of lymphocytes in viral infections. In Advances in Immunology 16 Edited by Dixon F. J., Kunkel M. H. New York: Academic Press;
    [Google Scholar]
  27. Woodward C. G., Smith H. 1974; Possible production of defective virus in the brains of mice by an avirulent, in contrast to a virulent, strain of Semliki Forest virus. Proceedings of the Society for General Microbiology 1:79
    [Google Scholar]
  28. Zisman B., Hirsch M. S., Allison A. C. 1970; Selective effects of antimacrophage serum, silica, and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. Journal of Immunology 1041155–1159
    [Google Scholar]
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