Two field strains of Ross River virus (RRV) which differed in virulence for laboratory mice were maintained without detectable change in virulence when passaged alternately in mosquitoes and newborn mice. No biological mechanism or selection pressure was identified to explain this suppression of the usual change to higher virulence observed when RRV is passed serially in infant mice. The maintenance of initial virulence by alternating passages appears to be related to the fact that can be infected only if fed on mice during the period of peak viraemia and that at this time a sub-population of higher virulence may not be present in high enough infectivity to be represented in the mosquito's blood meal.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error