1887

Abstract

SUMMARY

Sixty mutants were isolated from the Pacheco strain of type foot-and-mouth disease virus after treatment with either 5-fluorouracil or hydroxylamine. The conditions affecting recombination and assay of the recombinants were standardized. Using two mutants resistant to guanidine, three-factor crosses, supported by two-factor crosses, located 34 of the mutations in a linear arrangement. The recombination frequencies between certain pairs of mutations were additive. The guanidine character of the two resistant mutants mapped as a single site mutation and was located near the middle of the map.

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1975-06-01
2022-01-23
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References

  1. Benbow R. M., III Hutchison C. A., Fabricant J. D., Sinsheimer R. L. 1971; Genetic map of bacteriophage ϕX174. Journal of Virology 7:549–558
    [Google Scholar]
  2. Burge B. W., Pfefferkorn E. R. 1966; Complementation between temperature-sensitive mutants of Sindbis virus. Virology 30:214–223
    [Google Scholar]
  3. Cooper P. D. 1968; A genetic map of poliovirus temperature-sensitive mutants. Virology 35:584–596
    [Google Scholar]
  4. Cooper P. D. 1969 The genetic analysis of poliovirus. In The Biochemistry of Viruses pp. 177–218 Edited by Levy H. B. New York & London: Marcel Dekker;
    [Google Scholar]
  5. Cooper p. D., Geissler E., Scotti P. D., Tannock G. A. 1971 In Strategy of the Viral Genome pp. 75–100 Edited by Wolstenholme G. E. W. M. O’Connor, London: Churchill;
    [Google Scholar]
  6. Dahlberg J. E., Simon E. H. 1969; Physical and genetic studies of Newcastle disease virus: evidence for multiploid particles. Virology 38:666–678
    [Google Scholar]
  7. Epstein R. H., Bolle A., Steinberg C. M., Kellenberger E., Boyde La Tour E., Chevalley R., Edgar R. S., Susman M., Denhardt G. H., Leilausis A. 1963; Physiological studies of conditional lethal mutations of bacteriophage T4D. Cold Spring Harbor Symposia on Quantitative Biology 28:375–394
    [Google Scholar]
  8. Fenner R. 1970; The genetics of animal viruses. Annual Review of Microbiology 24:297–334
    [Google Scholar]
  9. Fields B. N., Joklik W. K. 1969; Isolation and preliminary genetic and biochemical characterisation of temperature-sensitive mutants of reovirus. Virology 37:335–342
    [Google Scholar]
  10. Ghendon Y. Z. 1972; Conditional-lethal mutants of animal viruses. Progress in Medical Virology 14:68–122
    [Google Scholar]
  11. Kawai S., Hanafusa H. 1972; Genetic recombination with avian tumour virus. Virology 49:37–44
    [Google Scholar]
  12. Lake J., Mackenzie J. S. 1973; Improved technique for the isolation of temperature-sensitive mutants of foot-and-mouth disease virus. Journal of Virology 21:665–668
    [Google Scholar]
  13. Mackenzie J. S. 1970; Isolation of temperature-sensitive mutants and the construction of a preliminary genetic map for influenza virus. Journal of General Virology 6:63–75
    [Google Scholar]
  14. Macpherson I. A., Stoker M. 1962; Polyoma transformation of hamster cell clones. An investigation of genetic factors affecting cell competence. Virology 16:147–151
    [Google Scholar]
  15. Pringle C. R. 1968; Recombination between conditional-lethal mutants within a strain of foot-and-mouth disease virus. Journal of General Virology 2:199–202
    [Google Scholar]
  16. Pringle C. R., Duncan I. B., Stevenson M. 1971; Isolation and characterisation of temperature-sensitive mutants of vesicular stomatitis virus, New Jersey serotype. Journal of Virology 8:836–841
    [Google Scholar]
  17. Pringle C. R., Slade W. R., Elworthy P., O’sullivan M. 1970; Properties of temperature-sensitive mutants of the Kenya 3/57 strain of foot-and-mouth disease virus. Journal of General Virology 6:213–220
    [Google Scholar]
  18. Ritchie D. A. 1973; Genetic analysis of animal viruses. British Medical Journal 29:947–952
    [Google Scholar]
  19. Russell W. C., Newman C., Williams J. F. 1972; Characterisation of temperature-sensitive mutants of adenovirus type 5. Serology. Journal of General Virology 17:265–279
    [Google Scholar]
  20. Simpson R. W., Hirst G. K. 1968; Temperature-sensitive mutants of influenza A virus. Isolation of mutants and preliminary observations on genetic recombination and complementation. Virology 35:41–49
    [Google Scholar]
  21. Thiry L. 1963; Chemical mutagenesis of Newcastle disease virus. Virology 19:225
    [Google Scholar]
  22. Vogt P. K. 1971; Genetically stable reassortment of markers during mixed infection with avian tumour viruses. Virology 46:947–952
    [Google Scholar]
  23. Vogt P. K. 1973; The genome of avian RNA tumour viruses: a discussion of four models. In Proceedings of IVLepetit Colloquium, Possible episomes in eukaryotes pp. 35–41 Edited by Silvestri L. Amsterdam: North Holland;
    [Google Scholar]
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