RT Journal Article SR Electronic(1) A1 Yamaguchi-Koll, Ursula A1 Wiegers, K. J. A1 Drzeniek, R.YR 1975 T1 Isolation and Characterization of ‘Dense Particles’ from Poliovirus-infected HeLa Cells JF Journal of General Virology, VO 26 IS 3 SP 307 OP 319 DO https://doi.org/10.1099/0022-1317-26-3-307 PB Microbiology Society, SN 1465-2099, AB SUMMARY Dense poliovirus particles (buoyant density 1.44 g/ml in CsCl) isolated from infected HeLa cells contain the normal four structural polypeptides VP1 to VP4, and 35S poliovirus RNA. In addition, small amounts of VP0 and single-stranded RNA sedimenting slower than the poliovirus genome are present. Dense particles have a low specific infectivity, are neutralized by type-specific poliovirus antisera, and are detected during growth as early as normal virus but disappear when virus production stops. They appear to represent a different, more open, conformation of the normal virus capsid., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-26-3-307