RT Journal Article SR Electronic(1) A1 Breinig, Mary C. A1 Armstrong, J. A. A1 Ho, M.YR 1975 T1 Rapid Onset of Hyporesponsiveness to Interferon Induction on Re-exposure to Polyribonucleotide JF Journal of General Virology, VO 26 IS 2 SP 149 OP 158 DO https://doi.org/10.1099/0022-1317-26-2-149 PB Microbiology Society, SN 1465-2099, AB SUMMARY Only doses of complexed polyriboinosinic: polyribocytidylic acids sufficient to induce interferon, stimulated hyporesponsiveness to re-induction in rabbit kidney cells. Results of experiments designed to delineate the earliest time of appearance of hyporesponsiveness suggested the time of onset was less than 1 h after the end of a 1 h exposure to the inducer. The duration of hyporesponsiveness was about 24 h. Interferon itself did not produce hyporesponsiveness. Hence hyporesponsiveness must be related to an event or a substance synthesized before interferon production. The best candidate is a control protein inhibiting interferon production which is rapidly synthesized following exposure to an inducer., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-26-2-149