RT Journal Article SR Electronic(1) A1 Von Boehmer, H. A1 Lehmann-Grube, F. A1 Flemer, Renate A1 Heuwinkel, R.YR 1974 T1 Multiplication of Lymphocytic Choriomeningitis Virus in Cultivated Foetal Inbred Mouse Cells and in Neonatally Infected Inbred Carrier Mice JF Journal of General Virology, VO 25 IS 2 SP 219 OP 228 DO https://doi.org/10.1099/0022-1317-25-2-219 PB Microbiology Society, SN 1465-2099, AB SUMMARY The replication of infectious LCM virus and its complement-fixing antigen was followed in cultivated foetal cells from colony-bred albino mice, foetal cells from CBA/Ca, C3H/HeJ, C57BL/6, and DBA/2 inbred mice, and L cells. Typical S-shaped growth curves were obtained in all instances and yields approached 104 intracerebral mouse ID50/cell. After the infection of newborn mice the multiplying virus rapidly reached a plateau of infectivity in tissues which remained thereafter. Ten weeks after neonatal infection the virus concentrations in blood and organs of ordinary albino mice and of CBA, C3H, C57BL/6, and DBA/2 inbred mice showed a wide range with highest levels in the kidneys and lowest in the blood. The multiplication patterns and maximum yields of infectious virus and complement-fixing antigen were essentially identical in L cells and in foetal cells derived from five mouse strains; mutatis mutandis the same was true for persisting virus in the blood and organs of neonatal carrier mice., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-25-2-219