The replication of infectious LCM virus and its complement-fixing antigen was followed in cultivated foetal cells from colony-bred albino mice, foetal cells from CBA/Ca, C3H/HeJ, C57BL/6, and DBA/2 inbred mice, and L cells. Typical S-shaped growth curves were obtained in all instances and yields approached 10 intracerebral mouse ID/cell. After the infection of newborn mice the multiplying virus rapidly reached a plateau of infectivity in tissues which remained thereafter. Ten weeks after neonatal infection the virus concentrations in blood and organs of ordinary albino mice and of CBA, C3H, C57BL/6, and DBA/2 inbred mice showed a wide range with highest levels in the kidneys and lowest in the blood.

The multiplication patterns and maximum yields of infectious virus and complement-fixing antigen were essentially identical in L cells and in foetal cells derived from five mouse strains; the same was true for persisting virus in the blood and organs of neonatal carrier mice.


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