Using a non-cytotoxic dose of ethidium bromide, a differential inhibitor of mitochondrial DNA and RNA synthesis, some early event(s), required after infection of Balb 3T3 cells with murine sarcoma virus, did not occur. This led to an inhibition of virus replication. The cells became refractory to inhibition 24 h after infection. The most effective inhibition was observed when cells were treated with ethidium bromide for 15 to 18 h before infection, suggesting the depletion of a cellular material involved in the establishment of virus infection. The degree of inhibition by ethidium bromide appeared to be affected by the multiplicity of infection.


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