Mouse L cells can be primed for enhanced interferon production by interferon covalently attached to beads of Sepharose. The induction of interferon synthesis by MM virus in primed cells can occur after removal of the interferon suggesting that interferon does not have to be in contact with the cell at the time of virus attachment. It is concluded that, like induction of the antiviral state, L cells can be primed at the cell surface for induction of interferon.


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