1887

Abstract

SUMMARY

In the immunization of mice with Sindbis virus, a central nervous system infection elicits greater cross protection against lethal challenges with Venezuelan equine encephalitis (VEE) virus than do infections initiated by extraneural routes. Infective Sindbis virus administered intraperitoneally, subcutaneously or intravenously was considerably less cross protective than a single inoculation of the virus into the cerebrum, yet similar levels of homologous neutralizing antibody at 28 days post-inoculation were elicited by the host, regardless of the route by which the virus was administered. Cross protection was correlated with invasion by, and replication of, Sindbis virus within the central nervous system and histopathological changes in the brain. The lowest levels of VEE virus infectivity were recovered from the brains of mice previously infected with Sindbis virus by the intracerebral route.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-24-3-401
1974-09-01
2024-04-18
Loading full text...

Full text loading...

/deliver/fulltext/jgv/24/3/JV0240030401.html?itemId=/content/journal/jgv/10.1099/0022-1317-24-3-401&mimeType=html&fmt=ahah

References

  1. Allen W. P. 1962; cross protection among group a arthropod-borne viruses. bacteriological proceedings p 152
    [Google Scholar]
  2. Brand O. M., Allen W. P. 1961; cross protection mechanism between sindbis and semliki forest viruses in mice. technical manuscript. no 159 united states army biological laboratories, fort detrick, md. u.s.a., 1–13
    [Google Scholar]
  3. Casals J. 1963; relationships among arthropod-borne animal viruses determined by cross-challenge tests. american journal of tropical medicine and hygiene 12:587–596
    [Google Scholar]
  4. Hammon W. Mcd., Sather G. E. 1956; immunity of hamsters to west nile and murray valley viruses following immunization with st louis and japanese b. proceedings of the society for experimental biology and medicine 91:521–524
    [Google Scholar]
  5. Hearn H. J., Rainey C. T. 1963; cross-protection in animals infected with group a arboviruses. journal of immunology 90:720–724
    [Google Scholar]
  6. Morgan I. M., Olitsky P. K., Scheslinger R. W. 1942; neutralizing antibody in cerebral spinal fluid in relation to cerebral resistance to equine encephalomyelitis virus. journal of bacteriology 43:83–84
    [Google Scholar]
  7. Porterfield J. S. 1960; a simple plaque-inhibition test for the study of arthropod-borne viruses. bulletin of the world health organization 22:373–380
    [Google Scholar]
  8. Price W. H., Parks J., Ganaway J., O’leary W., Lee R. 1963; the ability of an attenuated isolate of langat virus to protect primates and mice against other members of the russian spring-summer virus complex. american journal of tropical medicine and hygiene 12:787–799
    [Google Scholar]
  9. Taylor R. M. 1967 In catalogue of arthropod-borne viruses of the world157–160 (u.s. department of health, education and welfare) u.s. government printing office; washington, d.c. u.s.a:
    [Google Scholar]
  10. Thind L. S., Price W. H. 1968; passive transfer of acquired resistance in mice to group b arboviruses by serum protection factor(s) (spf) independent of serum neutralizing antibody or interferon. american journal of epidemiology 88:287–300
    [Google Scholar]
  11. Traub E. 1961; uber die immunitat der weissen maus gegenuber dem eee-virus: 7. weitere unter-suchungen uber die rolle der interferenz bei der cerebralen immunitat. zeitschrift fiir immunitatsfor-schung 122:229–238
    [Google Scholar]
  12. Wisseman C. I. Jun, Sweet B. H., Kitaoka M., Tamiya T. 1962; immunological studies with group b arthropod-borne viruses. i. broadened neutralizing antibody spectrum induced by strain 17d yellow fever vaccine in human subjects previously injected with japanese encephalitis virus. american journal of tropical medicine and hygiene 11:550–561
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-24-3-401
Loading
/content/journal/jgv/10.1099/0022-1317-24-3-401
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error