1887

Abstract

SUMMARY

Single-stranded polynucleotides (poly I and poly C), which do not generally have antiviral activity, became effective inducers of interferon when aggregated with different polycations. Poly I was consistently more active than poly C. The biological activity of the complexes depended more on the nature of the polycationic component than on the presence of the complementary base residue: introduction of covalently bound cytosine residue into the poly I—polybase complex did not have any significant effect.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-24-2-385
1974-08-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/24/2/JV0240020385.html?itemId=/content/journal/jgv/10.1099/0022-1317-24-2-385&mimeType=html&fmt=ahah

References

  1. Baron S., Bogomolova N. N., Billiau A., Levy H. G., Buckler C. E., Stern R., Naylor R. 1969; Induction of Interferon by Preparations of Synthetic Single Stranded RNA. Proceedings of the National Academy of Sciences of the United States of America 64:67–74
    [Google Scholar]
  2. Billiau A., Buckler C. E., Dianzani F., Uhlendorf C., Baron S. 1969; Induction of the Interferon Mechanism by Single Stranded RNA: Potentiation by Polybasic Substances. Proceedings of the Society of Experimental Biology and Medicine 132:790–796
    [Google Scholar]
  3. Carter W. A., Pitha P. M., Marshall L. W., Tazawa L., Tazawa S., Ts’O P. O. P. 1972; Structural Requirements of the rln.rCn Complex for Induction of Human Interferon. Journal of Molecular Biology 70:567–587
    [Google Scholar]
  4. Colby C. 1971; The Induction of Interferon by Natural and Synthetic Polynucleotides. In Progress in Nucleic Acid Research and Molecular Biology vol II333–360 Edited by Davidson J. N., Cohn W. E. New York and London: Academic Press;
    [Google Scholar]
  5. De Clercq E., Merigan T. C. 1969; Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides. Nature, London 222:1148–1152
    [Google Scholar]
  6. Doel M. T., Tones A. S., Taylor N. 1969; An Approach to the Synthesis of Peptide Analogues of Oligonucleotides (Nucleopeptides). Tetrahedron Letters No. 27 2285–2288
    [Google Scholar]
  7. Finter N. B. 1969; Dye Uptake Methods for Assessing Viral Cytopathogenicity and Their Application to Interferon Assays. Journal of General Virology 5:419–427
    [Google Scholar]
  8. Pitha P. M., Pitha J. 1971; Antiviral Resistance by the Polyinosinic Acid-Poly(I-vinylcytosine) Complex. Science, New York 172:1146–1148
    [Google Scholar]
  9. Pitha P. M., Pitha J. 1973; Interferon Induction Site; Poly IC on Solid Substrate Carriers. Journal of General Virology 21:31–37
    [Google Scholar]
  10. Phillips H. J., TerryBerry J. E. 1957; Counting of Actively Metabolizing Tissue Cultured Cells. Experimental Cell Research 13:341–347
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-24-2-385
Loading
/content/journal/jgv/10.1099/0022-1317-24-2-385
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error