1887

Abstract

SUMMARY

Abortive transformation of human embryonic fibroblasts was induced by virus. The parameters studied in order to test the establishment of a persistent infection and transformation of cells were: (1) virus interference and interferon production; (2) alterations of cell morphology and growth; (3) presence of neoantigens; (4) karyotype. The possible mechanisms leading to an abortive transformation are discussed.

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1974-08-01
2024-04-20
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References

  1. Dourmashkin R., Febvre H. L. 1958; Culture in vitro sur des cellules de la souche HeLa et identification au microscope electronique du virus du MoUuscum contagiosum. Compte rendu de I’Academie des sciences 346:2308–2310
    [Google Scholar]
  2. Fenner F., Woodroofe O. M. 1960; The reactivation of Poxviruses. II. The range of reactivating viruses. Virology II:185–201
    [Google Scholar]
  3. Friedman-Kien A. E., Vilcek J. 1967; Induction of interference and interferon synthesis by non-replicating Molluscum contagiosum virus. Journal of Immunology 99:1092–1098
    [Google Scholar]
  4. Hayflick L. 1965; The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research 37:614–636
    [Google Scholar]
  5. Hӓyry P., Defendi V. 1970; Surface antigens of SV40-transformed tumor cells. Virology 41:22–29
    [Google Scholar]
  6. Joklik W. K., Woodroofe G. M., Holmes I. H., Fenner F. 1960; The reactivation of Poxviruses. I. Demonstration of the phenomenon and techniques of assay. Virology n:168–184
    [Google Scholar]
  7. Koziorowska J., Wlodarski K., Mazurowa N. 1971; Transformation of mouse embryo cells by vaccinia virus. Journal of the National Cancer Institute 46:225–241
    [Google Scholar]
  8. La Placa M. 1966; On the mechanism of the cytopathic changes produced in human amnion cell cultures by the Molluscum contagiosum virus. Archiv fiir die gesamte Virusforschung 18:374–378
    [Google Scholar]
  9. La Placa M., Portolani M., Mannini-Palenzona A., Barbanti-Brodano G., Bernardini A. 1967a; Further studies on the mechanism of the cytopathic changes produced by the Molluscum contagiosum virus into human amnion cell cultures. Giornale di Microbiologia 15:205–216
    [Google Scholar]
  10. La Placa M., Portolani M., Rosa A. 1967b; Lack of reactivating activity in the Molluscum contagiosum virus. Archiv fiir die gesamte Virusforschung 20:251–255
    [Google Scholar]
  11. Macpherson L. 1970; The characteristics of animal cells transformed in vitro. Advances in Cancer Research 13:169–215
    [Google Scholar]
  12. Mӧller G. 1961; Demonstration of mouse isoantigens at the cellular level by the fluorescent antibody technique. Journal of Experimental Medicine 114:415–434
    [Google Scholar]
  13. Moorhead P. S., Nowell P. C. 1964; Chromosome cytology. Methods in Medical Research 10:310–322
    [Google Scholar]
  14. Neva F. A. 1962; Studies on Molluscum contagiosum. Observations on the cytopathic effect of Molluscum suspensions in vitro. Archives of Internal Medicine no:720–725
    [Google Scholar]
  15. Palm J., Heyner S., Brinster R. L. 1971; Differential immunofluorescence of fertilized mouse eggs with H-2 and non-H-2 antibody. Journal of Experimental Medicine 133:1282–1293
    [Google Scholar]
  16. Pirie G. D., Bishop P. M., Burke D. C., Postlethwaite R. 1971; Some properties of purified Molluscum contagiosum virus. Journal of General Virology 13:311–320
    [Google Scholar]
  17. Postlethwaite R. 1964; Antiviral Activity in extracts from lesions of Molluscum contagiosum. Virology 22:508–519
    [Google Scholar]
  18. Postlethwaite R. 1970; Molluscum contagiosum. A review. Archives of Environmental Health 21:432–452
    [Google Scholar]
  19. Roosa R. A., Bailey E. 1970; DNA-mediated transformation of mammalian cells in culture: increased transforming efficiency following sonication. Journal of Cellular Physiology 75:137–150
    [Google Scholar]
  20. Stoker M. 1968; Abortive transformation by polyoma virus. Nature, London 218:234–238
    [Google Scholar]
  21. Ueda Y., Ito M., Tagaya I. 1969; A specific surface antigen induced by Poxvirus. Virology 38:180–182
    [Google Scholar]
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