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Abortive transformation of human embryonic fibroblasts was induced by Molluscum contagiosum virus. The parameters studied in order to test the establishment of a persistent infection and transformation of cells were: (1) virus interference and interferon production; (2) alterations of cell morphology and growth; (3) presence of neoantigens; (4) karyotype. The possible mechanisms leading to an abortive transformation are discussed.
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