1887

Abstract

SUMMARY

The compound ICI 65,709 is a substituted guanidine which has antiviral activity in human embryo lung cells (Bucknall ., 1973). We have found that ICI 65,709 reversibly inhibits the synthesis of RNA by rhinovirus type 2. The three species of virus RNA were equally affected. Comparison of the effect with that of guanidine, a well known inhibitor of picornavirus RNA synthesis, showed that ICI 65,709 and guanidine mediated their antiviral effects in different ways. This conclusion was supported by the failure of ICI 65,709 to inhibit multiplication of a bovine enterovirus which was inhibited by guanidine. ICI 65,709 also inhibited the multiplication of poliovirus type 1.

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/content/journal/jgv/10.1099/0022-1317-23-3-341
1974-06-01
2024-04-19
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References

  1. Acornley J. E., Chapple J., Stott E. J., Tyrrell D. A. J. 1968; Selection of variants of rhinoviruses. Archiv fur die gesamte Virusforschung 23:284–287
    [Google Scholar]
  2. Bablanian R., Eggers H. J., Tamm I. 1965; Studies on the mechanism of poliovirus-induced cell damage. 1. The relation between poliovirus-induced metabolic and morphological alteration in cultured cells. Virology 26:100–113
    [Google Scholar]
  3. Baltimore D. 1969; The replication of picornaviruses. In Biochemistry of Viruses101–176 Edited by Levy H. B. New York and London: Marcel Dekker;
    [Google Scholar]
  4. Bucknall R. A., Swallow D. L., Moores H., Harrad J. 1973; A novel substituted guanidine with high activity in vitro against rhinoviruses. Nature, London 246:144–145
    [Google Scholar]
  5. Caliguiri L. A., Tamm I. 1968; Action of guanidine on the replication of poliovirus RNA. Virology 35:408–417
    [Google Scholar]
  6. Koliais S. I., Dimmock N. J. 1973; Replication of rhinovirus RNA. Journal of General Virology 20:1–15
    [Google Scholar]
  7. Lwoff A. 1965; The specific inhibitors of viral development. Biochemical Journal 96:289–301
    [Google Scholar]
  8. Sergiescu D., Horodniceanu F., Aubert-Combiescu A. 1972; The use of inhibitors in the study of picoma-virus genetics. Progress in Medical Virology 14:123–199
    [Google Scholar]
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