Necessity for the 2′-Hydroxyl Group for the Antiviral Activity of Synthetic Polynucleotides Free

Abstract

SUMMARY

Hybrids from poly dI and poly r(5-halogenocytidylic acids) having ’s in the region of 60 °C are inactive as interferon inducers thus confirming the requirement for a free 2′-hydroxyl group in both the poly I and poly C strands of poly rI.poly rC.

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1974-06-01
2024-03-29
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