@article{mbs:/content/journal/jgv/10.1099/0022-1317-23-3-331, author = "Hutchinson, D. W. and Johnston, M. D. and Eaton, M. A. W.", title = "Necessity for the 2′-Hydroxyl Group for the Antiviral Activity of Synthetic Polynucleotides", journal= "Journal of General Virology", year = "1974", volume = "23", number = "3", pages = "331-333", doi = "https://doi.org/10.1099/0022-1317-23-3-331", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-23-3-331", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY Hybrids from poly dI and poly r(5-halogenocytidylic acids) having T m’s in the region of 60 °C are inactive as interferon inducers thus confirming the requirement for a free 2′-hydroxyl group in both the poly I and poly C strands of poly rI.poly rC.", }