Cultures of brain cells taken from mice at 1 to 3 days after peripheral infection with Chikungunya virus, showed loss of contact inhibition and morphological alterations which suggested that these cells may have been transformed. In cultures infected with a low dose of about 10 LD/ml of culture medium, areas of epithelial-like cells and hypertrophied cells were dominant, cultures were destroyed after infection with a high dose of about 10 LD/ml of culture medium. Cultures not destroyed by virus were studied for up to 4 months. The supernatant fluids of these cultures were titrated regularly in an adult mouse system in which the amounts of virus recorded varied from 10 to 10 LD/ml.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error