Murine Sarcoma Virus-induced Cytopathological Effects in Mouse Cells made Resistant to 6-Azauridine

Mouse cells made resistant to 6-azauridine were found to undergo syncytium formation upon infection with the Rauscher pseudotype of Moloney sarcoma virus (M-MSV(RLV)) and the Moloney strain of murine sarcoma virus (M-MSV(MLV)). The formation of syncytia was related to sarcoma virus replication since syncytia were never produced by leukaemia virus alone or by β-propiolactone-inactivated M-MSV(RLV).