RT Journal Article SR Electronic(1) A1 Taylor, M. W. A1 Su, R. A1 Cordell-Stewart, Barbara A1 Morgan, S. A1 Crisp, M. A1 Hodes, M. E.YR 1974 T1 Bovine Enterovirus-1: characterization, Replication and Cytopathogenic Effects JF Journal of General Virology, VO 23 IS 2 SP 173 OP 178 DO https://doi.org/10.1099/0022-1317-23-2-173 PB Microbiology Society, SN 1465-2099, AB SUMMARY The biological parameters of a bovine picornavirus, bovine enterovirus-1, are described. The virus is shown to have a rapid growth cycle and to be stable over an extended period at 56 °C and at pH 2 to 10. Within the first hour of infection of cells with BEV-1, cellular protein synthesis was inhibited to less than 40% of normal levels. Maximum release of progeny virus occurred 6 to 8 h post-infection, which coincided with the time of maximum cytopathogenic effects as seen by electron microscopy. The synthesis of virus-specific RNA commenced 1 to 2 h after infection and proceeded exponentially until 5 h after infection. Four virus capsid polypeptides were found together with procapsid proteins, one of which appeared to be a precursor of VP2 and VP4., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-23-2-173