%0 Journal Article %A Pani, P. K. %T Studies in Genetic Resistance to RSV (RAV-O) %D 1974 %J Journal of General Virology, %V 23 %N 1 %P 33-40 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-23-1-33 %I Microbiology Society, %X SUMMARY Embryos of the highly inbred Reaseheath W line were found to be resistant to RSV (RAV-O), a subgroup E virus. The results of test-cross matings between this line and the inbred Reaseheath I and C lines confirmed the two-loci genetic model reported previously by us for inheritance of response of fowl to RSV (RAV-O). Two loci were postulated in this model. Inhibitor e , with resistance Ie allele dominant over ie , and tumour virus e (tve), with susceptibility allele es dominant over resistance allele er . Ie is epistatic to es , inhibiting its expression. The genotype of the W line was typified as IeIeerer , a third type of resistance (Type III), and the first two types, IeIeeses and ieieerer , were reported in our previous communication for the I and C lines, respectively. It was found in certain crosses that embryos resistant to subgroup B virus were also resistant to RSV (RAV-O), but embryos susceptible to subgroup B virus were found segregating for resistance to subgroup E virus. This type of segregation failed to support the concept advanced by other workers that the association between the two types of resistance was dependent on genes at the tvb locus. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-23-1-33