Human Serum Lipoproteins as Inhibitors of Haemagglutination for Selected Togaviruses

Human serum was fractionated by ultracentrifuging and the non-specific inhibitory activity for the togaviruses, Japanese encephalitis virus and rubella virus, was found chiefly in the very low density lipoprotein (VLDL) and low density lipoprotein (LDL) fractions. The specific inhibitory activity per mg protein or lipid of each lipoprotein fraction was greater for Japanese encephalitis virus. Japanese encephalitis virus was significantly more sensitive to VLDL than LDL whereas rubella virus was equally sensitive to either.