1887

Abstract

SUMMARY

The existence of defective interfering (DI) particles has been well documented for a number of virus systems (Huang & Baltimore, 1970). Such particles are currently of great interest since their ability to cause homologous interference has been implicated as a possible regulatory factor in the establishment of chronic or persistent virus disease (Huang & Baltimore, 1970). We have recently reported that about 50 cell generations after infection of BHK 21/13S cells with either lymphocytic choriomeningitis virus (LCMV) or Parana virus, infective virus could no longer be detected in either the cells or the culture medium (Staneck ., 1972). However, LCMV-infected cultures continued to produce particles with an interference activity which closely resembled DI virus (Welsh, O′Connell & Pfau, 1972). The data presented here indicate that Parana, another arenavirus (Rowe ., 1970), can initiate the nearly exclusive synthesis of DI virus under the same conditions.

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/content/journal/jgv/10.1099/0022-1317-22-3-437
1974-03-01
2021-10-22
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References

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