1887

Abstract

SUMMARY

The sensitivity to actinomycin D of the early steps of the replication of murine sarcoma virus (Moloney) (M-MSV) was investigated by treating infected mouse cells with the antibiotic (0.25 µg/ml) for 6 h periods at several times after infection. The results obtained indicate that M-MSV production is inhibited when actinomycin D is added within 2½ h of infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-22-2-293
1974-02-01
2024-11-12
Loading full text...

Full text loading...

/deliver/fulltext/jgv/22/2/JV0220020293.html?itemId=/content/journal/jgv/10.1099/0022-1317-22-2-293&mimeType=html&fmt=ahah

References

  1. Bader J. P. 1972; Metabolic requirements for infection by Rous sarcoma virus. III. The synthesis of viral DNA. Virology 48:485–493
    [Google Scholar]
  2. Bases R. E., King A. S. 1967; Inhibition of Rauscher murine leukaemia vims growth ‘in vitro’ by actino-mycin D. Virology 33:175–183
    [Google Scholar]
  3. Bernard C., Guillemain B., Peries J., Boiron M. 1968; Conversion cellulaire provoquee ‘in vitro’ par le virus du sarcome murin (Moloney). Analyse de la courbe dose-reponse. International Journal of Cancer 3:558–565
    [Google Scholar]
  4. Buck B. M., Bather R. 1969; Requirements for RNA and DNA synthesis in the transformation of mouse embryo cells by murine sarcoma virus (Moloney). Journal of General Virology 4:457–460
    [Google Scholar]
  5. Duc Nguyen H. 1968; Enhancing effect of diethylaminoethyl-Dextran on the focus-forming titer of a murine sarcome virus (Harvey strain). Journal of Virology 2:643–644
    [Google Scholar]
  6. Duesberg P. H., Robinson W. S. 1967; Inhibition of mouse leukaemia virus (MLV) replication by actinomycin D. Virology 31:742–746
    [Google Scholar]
  7. Guillemain B., Laumond J., Godard C., Boiron M. 1971; Dissociation between cell conversion induced by mouse sarcoma virus and production of infectious virus. Journal of General Virology 10:91–93
    [Google Scholar]
  8. McDonnell J. P., Garapin A. C., Levinson W. E., Quintrell N., Fanshier L., Bishop J. M. 1970; DNA polymerases of Rous sarcoma virus: delineation of two reactions with actinomycin D. Nature, London 228:433–435
    [Google Scholar]
  9. Murray R. K., Temin H. M. 1970; Carcinogenesis by RNA sarcoma viruses. XIV. Infection of stationary cultures with murine sarcoma virus (Harvey). International Journal of Cancer 5:320–326
    [Google Scholar]
  10. Robinson H. L. 1967; Isolation of noninfectious particles containing Rous sarcoma virus RNA from the medium of Rous sarcoma virus-transformed non-producer cells. Proceedings of the National Academy of Sciences of the United States of America 57:1655–1662
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-22-2-293
Loading
/content/journal/jgv/10.1099/0022-1317-22-2-293
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error