Following the adsorption of u.v.-inactivated Sendai virus at high multiplicity on to HeLa-S3 or L-929 cells there was a transient inhibition of uptake of amino acids into the cells, but no inhibition of protein synthesis. The uptake of amino acids into virus-treated cells was maximally inhibited at the end of the adsorption period, but within a few hours returned to control level.
The changes in the uptake of amino acids occurred concomitantly with enhanced potassium uptake and with inhibition of DNA synthesis, but were of longer duration.
AllenE. H.,
SchweetR. S.1962; Synthesis of hemoglobin in a cell-free system. I. Properties of the complete system. Journal of Biological Chemistry 237:760–767
FuchsP.,
KohnA.1971; Nature of transient inhibition of deoxyribonucleic acid synthesis in HeLa cells by Parainfluenza virus i (Sendai). Journal of Virology 8:695–700
FuchsP.,
GibermanE.1973; Enhancement of potassium influx in baby hamster kidney cells and chicken erythrocytes during adsorption of Parainfluenza 1 (Sendai) virus. Federation of European Biochemical Society Letters 31:127–130
HuangA. S.,
WagnerR. R.1965; Inhibition of cellular RNA synthesis by non-replicating vesicular stomatitis virus. Proceedings of National Academy of Sciences of the United States of America 54:1579–1584
MartinE. M.,
KerrI. M.1968; Virus induced changes in host-cell macromolecular synthesis. In The Molecular Biology of Viruses, pp. 15–46 Edited by
CrawfordL. V.,
StokerM. G. P.
Cambridge: Cambridge University Press;
MeiselmanN.,
KohnA.,
DanonD.1967; Electron microscopic study of penetration of Newcastle disease virus into cells leading to formation of polykaryocytes. Journal of Cell Science 2:71–76
MorganC.,
HoweC.1968; Structure and development of viruses as observed in the electron microscope. IX. Entry of Parainfluenza i (Sendai) virus. Journal of Virology 2:1122–1132
YamashitaT.,
MoritsuguY.,
ShimojoH.1971; Suppression of cellular DNA synthesis in growing cells by ultraviolet-irradiated adenoviruses. Virology 45:687–696
YaoiY.,
MitsuiH.,
AmanoM.1970; Effect of UV-irradiated vesicular stomatitis virus on nucleic acid synthesis in chick embryo cells. Journal of General Virology 8:165–172