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At 30 to 60 min after infection of primary rabbit kidney cells with Shope fibroma virus, the majority of virus particles were found within dense granules identified as lysosomes, whereas by 24 h no particles could be observed. The lysosomes appeared to become more fragile as infection proceeded, cellular proteins being progressively released from 7 to 24 h. Extracted lysosomal enzymes had no effect on purified Shope fibroma virus.
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