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1887

Abstract

SUMMARY

Of eleven virus-specific antigens detected in cells infected with herpes simplex virus type 1, six have been shown to be type specific, i.e. not present in cells infected with type 2 virus. Two of the five type common antigens are also present in cells infected with pseudorabies virus. Electron microscopic studies of immune agglutination of virus particles have shown that both naked and enveloped particles possess type specific and type common antigenic determinants on their surface. Further, one of the type common determinants on the naked particle surface interacted with antiserum to pseudorabies virus.

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/content/journal/jgv/10.1099/0022-1317-22-2-159
1974-02-01
2025-04-23
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References

  1. Bronson D. L., Graham B. J., Ludwig H. O., Benyesh-Melnick M., Biswal N. 1972; Studies on the relatedness of herpes viruses through DNA-RNA hybridization. Biochimica biophysica acta 259:24–34
    [Google Scholar]
  2. Buchan A., Luff S., Wallis C. 1970; Failure to demonstrate interaction of subunits of thymidine kinase in cells simultaneously infected with herpes virus and a kinaseless mutant. Journal of General Virology 9:239–242
    [Google Scholar]
  3. Buchan A., Watson D. H. 1969; The immunological specificity of thymidine kinases in cells infected by viruses of the herpes group. Journal of General Virology 4:461–463
    [Google Scholar]
  4. Dreesman G. R., Suriano J. R., Swartz S. K., McCombs R. M. 1972; Characteristics of the herpes virus. I. Purification and amino acid composition of nucleocapsids. Virology 50:528–534
    [Google Scholar]
  5. Dubbs D. R., Kit S. 1964; Mutant strains of herpes simplex deficient in thymidine kinase-inducing ability. Virology 22:493–502
    [Google Scholar]
  6. Dulbecco R., Vogt M. 1954; Plaque formation and isolation of pure lines with poliomyelitis viruses. Journal of Experimental Medicine 99:167–182
    [Google Scholar]
  7. Honess R. W., Watson D. H. 1974; Herpes virus-specific polypeptides studied by polyacrylamide gel electrophoresis of immune precipitates. Journal of General Virology 22:171–185
    [Google Scholar]
  8. Keir H. M., Subak-Sharpe H., Shedden W. I. H., Watson D. H., Wildy P. 1966; Immunological evidence for a specific DNA polymerase produced after infection by herpes simplex virus. Virology 30:154–157
    [Google Scholar]
  9. Kieff E., Hoyer B., Bachenheimer S., Roizman B. 1972; Genetic relatedness of type 1 and type 2 herpes simplex viruses. Journal of Virology 9:738–745
    [Google Scholar]
  10. Kirkwood J., Geering G., Old L. J. 1972; Demonstration of group- and type-specific antigens of herpes viruses. In Oncogenesis and Herpes Viruses p 479 Edited by Biggs P. M., de-Thé G., Payne L. N. Lyons: IARC;
    [Google Scholar]
  11. Klemperer H. G., Haynes G. R., Shedden W. I. H., Watson D. H. 1967; A virus-specific thymidine kinase in BHK 21 cells infected with herpes simplex virus. Virology 31:120–128
    [Google Scholar]
  12. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193:265–275
    [Google Scholar]
  13. Ludwig H. O., Biswal N., Benyesh-Melnick M. 1972; Studies on the relatedness of herpes viruses through DNA-DNA hydridization. Virology 49:95–101
    [Google Scholar]
  14. Morrison J. M., Keir H. M. 1968; A new DNA-exonuclease in cells infected with herpes virus: partial purification and properties of the enzyme. Journal of General Virology 3:337–347
    [Google Scholar]
  15. Robinson D. J., Watson D. H. 1971; Structural proteins of herpes simplex virus. Journal of General Virology 10:163–171
    [Google Scholar]
  16. Schneweis K. E., Nahmias A. J. 1971; Antigens of herpes simplex virus type 1 and 2 - immunodiffusion and inhibition passive haemagglutination studies. Zeitschrift für Immunitӓtsforschung und experimentelle Therapie 141:471–487
    [Google Scholar]
  17. Sim C., Watson D. H. 1973; The role of type specific and cross reacting structural antigens in the neuralization of herpes simplex virus types 1 and 2. Journal of General Virology 19:217–233
    [Google Scholar]
  18. Thouless M. E. 1972; Serological properties of thymidine kinase produced in cells infected with type 1 or type 2 herpes virus. Journal of General Virology 17:307–316
    [Google Scholar]
  19. Watson D. H. 1962; Particle counts on herpes virus in phosphotungstate negatively stained preparations in electron microscopy. 5th International Congress for Electron Microscopy (Philadelphia, U.S.A.) vol 2:X4 Edited by Breese S. S.
    [Google Scholar]
  20. Watson D. H. 1969; The separation of herpes virus specific antigens by polyacrylamide gel electrophoresis. Journal of General Virology 4:151–161
    [Google Scholar]
  21. Watson D. H., Shedden W. I. H., Elliot A., Tetsuka T., Wildy P., Bourgaux-Ramoisy D., Gold E. 1966; Virus specific antigens in mammalian cells infected with herpes simplex virus. Immunology 27:399–418
    [Google Scholar]
  22. Watson D. H., Wildy P. 1963; Some serological properties of herpes virus particles studied with the electron microscope. Virology 21:100–111
    [Google Scholar]
  23. Watson D. H., Wildy P. 1969; The preparation of ‘monoprecipitin’ antisera to herpes virus specific antigens. Journal of General Virology 4:163–168
    [Google Scholar]
  24. Watson D. H., Wildy P., Harvey B. A. M., Shedden W. I. H. 1967; Serological relationships among viruses of the herpes group. Journal of General Virology 1:139–147
    [Google Scholar]
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