1887

Abstract

SUMMARY

The effect of interferon on interferon induction either by NDV or poly I:C was studied. A priming effect of NDV-induced interferon was obtained after pretreatment of the cells for 24 h with low concentrations of homologous interferon. After pre-treatment with higher doses, interferon production was diminished. Purified homologous interferon preparations had a biological effect similar to that of unpurified preparations, while purified heterologous interferon had no effect. The destruction of the interferon molecule or of ‘associated proteins’ by trypsin abolished the blocking effect. Similar results were obtained when poly I:C was used, instead of NDV, as an inducer. In somatic monkey-mouse hybrid cells, mouse or monkey interferon was effective in blocking mouse or monkey interferon synthesis. In clones weakly sensitive to primate interferon, no significant effect was observed.

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1974-01-01
2021-10-20
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References

  1. Andrews P. 1964; Estimation of the molecular weight of proteins by Sephadex gel filtration. Biochemical Journal 91:222–233
    [Google Scholar]
  2. Bausek G. H., Merigan T. C. 1970; Two mechanisms of cell resistance to repeated stimulation of interferon. Proceedings of the Society for Experimental Biology and Medicine 134:672–676
    [Google Scholar]
  3. Borden E. C., Murphy F. A. 1971; The interferon refractory state: In vivo and in vitro studies of its mechanism. The Journal of Immunology 106:134–142
    [Google Scholar]
  4. Burke D. C., Buchan A. 1965; Interferon production in chick embryo cells. I - Production by ultraviolet-inactivated virus. Virology 26:28–35
    [Google Scholar]
  5. Cassingena R., Chany C., Vignal M., Suarez H. G., Estrade S., Lazar P. 1971; Use of monkey-mouse hybrid cells for the study of the cellular regulation of interferon production and action. Proceedings of the National Academy of Sciences of the United States of America 68:580–584
    [Google Scholar]
  6. Chany C., Vignal M. 1968; Etude du mécanisme de l’état réfractaire des cellules a la production d’interféron, aprés inductions répétées. Compte rendu de l'Académie des sciences, Paris 267:1798–1800
    [Google Scholar]
  7. Chany C., Vignal M. 1970; Effect of prolonged interferon treatment on mouse embryonic fibroblasts transformed by murine sarcoma virus. Journal of General Virology 7:203–210
    [Google Scholar]
  8. Falcoff E., Falcoff R., Fournier F., Chany C. 1966; Production en masse, purification partielle et caractérisation d’un interferon destine a des essais thérapeutiques humains. Annales de l' Institut Pasteur 111:562–584
    [Google Scholar]
  9. Finter N. B. 1964; A rich source of mouse interferon. Nature, London 204:1114–1115
    [Google Scholar]
  10. Friedman R. M. 1966; Effect of interferon treatment on interferon production. Journal of Immunology 96:872–877
    [Google Scholar]
  11. Gresser I. 1961; Production of interferon by suspensions of human leucocytes. Proceedings of the Society for Experimental Biology and Medicine 108:799–803
    [Google Scholar]
  12. Levy H. B., Buckler C. E., Baron S. 1966; Effect of interferon on early interferon production. Science, New York 152:1274–1276
    [Google Scholar]
  13. Lockart R. Z. Jun 1963; Production of an interferon by L cells infected with Western Equine encephalomyelitis virus. Journal of Bacteriology 85:556–566
    [Google Scholar]
  14. Margolis S. A., Oie H., Levy H. B. 1972; The effect of interferon, interferon inducers or interferon induced virus resistance on subsequent interferon production. Journal of General Virology 15:119–128
    [Google Scholar]
  15. Ng M. H., Berman B., Vilcek J. 1972; Membrane-bound intracellular interferon in rabbit kidney cell cultures. Virology 49:322–325
    [Google Scholar]
  16. Paucker K., Boxaca M. 1967; Cellular resistance to induction of interferon. Bacteriological Reviews 31: (2) 145–156
    [Google Scholar]
  17. Paucker K., Stancek D. 1972; Characterization of interferon-associated proteins. Journal of General Virology 15:129–138
    [Google Scholar]
  18. Rousset S., Fournier F., Chany C. 1970; Recherche d’une correlation entre l’état réfractaire la synthése de l’interféron et l’état de resistance antivirale. Compte rendu de l'Académie des sciences, Paris 271:267–269
    [Google Scholar]
  19. Stewart W. E. II, De Clerq E., Billiau A., Desmyter J., DeSomer P. 1972; Increased susceptibility of cells treated with interferon to the toxicity of polyriboinosinic. polyribocytidylic acid. Proceedings of the National Academy of Sciences of the United States of America 69:1851–1854
    [Google Scholar]
  20. Stewart W. E. II, Gosser L. B. Jun, Lockart R. Z. 1971a; Distinguishing characteristics of the interferon responses of primary and continuous mouse cell cultures. Journal of General Virology 13:35–50
    [Google Scholar]
  21. Stewart W. E. II, Gosser L. B., Lockart R. Z. Jun 1971b; Priming a non-antiviral function of interferon. Journal of Virology 7:792–801
    [Google Scholar]
  22. Suarez H. G., Chany C., Cassingena R., Vignal M., Lemaitre J. 1972; Localisation du chromosome responsable de la synthése de l’interféron simien. Compte rendu de l'Académie des sciences, Paris 274:3632–3634
    [Google Scholar]
  23. Tan Y. H., Armstrong J. A., Ke Y. H., Ho M. 1970; Regulation of cellular interferon production: enhancement by antimetabolites. Proceedings of the National Academy of Sciences of the United States of America 67:464–471
    [Google Scholar]
  24. Vilcek J. 1962; Studies on an interferon from tick-borne encephalitis virus-infected cells (IF). IV. Comparison of interferon with interferon from influenza virus-infected cells. Acta virologica 6:144–150
    [Google Scholar]
  25. Vilcek J. 1970; Cellular mechanisms of interferon production. Journal of General Physiology 56:76s–89s
    [Google Scholar]
  26. Vilcek J., Ng M. H. 1971; Post-transcriptional control of interferon synthesis. Journal of Virology 7:588–594
    [Google Scholar]
  27. Vilcek J., Rada B. 1962; Studies on an interferon from tick-borne encephalitis virus-infected cells (IF). III. Antiviral action of interferon. Acta virologica 6:9–16
    [Google Scholar]
  28. Youngner J. S., Hallum J. V. 1969; Inhibition of induction of interferon synthesis in L cells pre-treated with interferon. Virology 37:473–475
    [Google Scholar]
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