The effect of interferon on interferon induction either by NDV or poly I:C was studied. A priming effect of NDV-induced interferon was obtained after pretreatment of the cells for 24 h with low concentrations of homologous interferon. After pre-treatment with higher doses, interferon production was diminished. Purified homologous interferon preparations had a biological effect similar to that of unpurified preparations, while purified heterologous interferon had no effect. The destruction of the interferon molecule or of ‘associated proteins’ by trypsin abolished the blocking effect. Similar results were obtained when poly I:C was used, instead of NDV, as an inducer. In somatic monkey-mouse hybrid cells, mouse or monkey interferon was effective in blocking mouse or monkey interferon synthesis. In clones weakly sensitive to primate interferon, no significant effect was observed.


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