Some but not all of the mouse L cell strains carry virus particles which have been found to be morphologically, biochemically and antigenically indistinguishable from known RNA tumour viruses. Present electron microscopic study has revealed that cultures of two of the clones derived from NCTN 929 cells when grown in Eagle's medium enriched with foetal calf serum contained a few intracisternal A-type virus-like particles but were continuously negative for C-type virus particles. Exposure of the cultures to the drug cytochalasin B resulted in the appearance of abundant intracytoplasmic and extracellular C-type virus particles. Possible mechanisms of the activation of virus synthesis and release by cytochalasin B are discussed.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error