@article{mbs:/content/journal/jgv/10.1099/0022-1317-21-2-413, author = "Tanaka, J. and Hatano, M.", title = "The Effect of Trypsin on the Formation of Virus-specific Surface Antigen in Cowpox Virus-infected Cells", journal= "Journal of General Virology", year = "1973", volume = "21", number = "2", pages = "413-416", doi = "https://doi.org/10.1099/0022-1317-21-2-413", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-21-2-413", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "SUMMARY Poxvirus infection results in the production of virus-specific surface antigen (S-antigen) which is clearly distinguished from intra-cytoplasmic virus antigen (V-antigen) (Miyamoto & Kato, 1968, 1971; Ueda, Ito & Tagaya, 1969). In a study of the development of these antigens in several different established cell lines, we observed that some cells are relatively poor producers of S- and V-antigens and that in these cells treatment with trypsin markedly enhances S-antigen production but not V-antigen production.", }