The Effect of Frog Virus 3 on the Biological Activity of various RNA Viruses

Frog virus 3 inhibits the replication of various RNA viruses: nuclear and cytoplasmic, coated and uncoated, large and small. The inhibition is apparent at 37 °C, a non-permissive temperature for frog virus 3. Frog virus 3 particles must be present in the cell during the RNA replication in order to achieve inhibition. Our results indicate that the inhibition occurs in the early stages of virus replication.