RT Journal Article SR Electronic(1) A1 Ustacelebi, S. A1 Williams, J. F.YR 1973 T1 Induction of Interferon in Chick Cells by Polyoma Virus JF Journal of General Virology, VO 21 IS 1 SP 163 OP 168 DO https://doi.org/10.1099/0022-1317-21-1-163 PB Microbiology Society, SN 1465-2099, AB SUMMARY Polyoma virus induces high levels of interferon in non-permissive chick embryo fibroblast cultures, and certain features of this induction have been examined. In non-pre-treated cultures interferon first appears at around 30 h after infection and reaches maximum levels at around 70 h. An input multiplicity of at least 0.5 p.f.u./cell is required for induction. In cultures pre-treated with interferon (primed), interferon induction is enhanced, with interferon first appearing in the medium at around 20 h and reaching 4- to 8-fold higher levels than in non-primed cultures. In this case interferon is induced by an input multiplicity of as low as 0.1 p.f.u./cell. ‘Full’ or intact polyoma particles induce, but ‘empty’ shells do not. Interferon can also be induced by polyoma on continuously passaged lines of chick embryo fibroblasts., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-21-1-163