1887

Abstract

Summary

Polyoma virus induces high levels of interferon in non-permissive chick embryo fibroblast cultures, and certain features of this induction have been examined. In non-pre-treated cultures interferon first appears at around 30 h after infection and reaches maximum levels at around 70 h. An input multiplicity of at least 0.5 p.f.u./cell is required for induction. In cultures pre-treated with interferon (primed), interferon induction is enhanced, with interferon first appearing in the medium at around 20 h and reaching 4- to 8-fold higher levels than in non-primed cultures. In this case interferon is induced by an input multiplicity of as low as 0.1 p.f.u./cell. ‘Full’ or intact polyoma particles induce, but ‘empty’ shells do not. Interferon can also be induced by polyoma on continuously passaged lines of chick embryo fibroblasts.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-21-1-163
1973-10-01
2019-10-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-21-1-163
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error