Strains of herpes simplex virus types 1 and 2 were used to infect 3-day-old cultures of chick embryo dorsal root ganglia. Evidence of c.p.e. was seen by means of light microscopy at 14 h after infection. Ganglia were removed at intervals after infection and fixed and sectioned for electron microscopy. All stages of virus replication were observed in neurons, while few glial cells showed evidence of infection. Glial cells which did appear to have become infected showed signs of defective virus replication. The significance of the findings are discussed in relation to the mechanism of latency in herpes simplex virus infections.


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