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Accumulation of intracellular mengovirus was studied in single, isolated mouse L cells. Pre-treatment with interferon delayed the initiation of virus replication in most cells, with the amount of delay varying widely from cell to cell. However, once the accumulation of intracellular virus began, it proceeded at an approximately normal rate. The data suggest that within a cell at any given moment, the action of interferon is usually all or nothing. That is, virus production is either totally inhibited, or free to proceed normally.
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