1887

Abstract

SUMMARY

Accumulation of intracellular mengovirus was studied in single, isolated mouse L cells. Pre-treatment with interferon delayed the initiation of virus replication in most cells, with the amount of delay varying widely from cell to cell. However, once the accumulation of intracellular virus began, it proceeded at an approximately normal rate. The data suggest that within a cell at any given moment, the action of interferon is usually all or nothing. That is, virus production is either totally inhibited, or free to proceed normally.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-20-2-139
1973-08-01
2023-02-01
Loading full text...

Full text loading...

/deliver/fulltext/jgv/20/2/JV0200020139.html?itemId=/content/journal/jgv/10.1099/0022-1317-20-2-139&mimeType=html&fmt=ahah

References

  1. Chany C., Fournier F., Roussett S. 1970 Annals of the New York Academy of Science 173:505–515
    [Google Scholar]
  2. Chano T. T. 1972; Studies on the mechanism of interferon action in single cells: Accumulation of intercellular virus. M.S. Thesis Purdue University;
    [Google Scholar]
  3. Choppin P. W. 1964; Multiplication of SV5 with minimal cytopathic effects and without interference. Virology 23:224–233
    [Google Scholar]
  4. Fleischmann W. R. Jun 1972; Part I. Induction of interferon. Part II. Response of L cells to interferon mediated protection. PhD Thesis Purdue University;
    [Google Scholar]
  5. Fleischmann W. R. Jun, Simon E. H. 1973; Interferon mediated delay of mengovirus production in isolated, single L cells. Journal of General Virology 20:127–137
    [Google Scholar]
  6. Guskey L. E., Smith P. C., Wolff D. A. 1973; Patterns of cytopathology and lysosomal enzyme treated with either 2-(-Hydroxybenzyl)-benzimidazole or guanidine HC1. Journal of General Virology 6:151–161
    [Google Scholar]
  7. Hallum J. V., Youngner J. S. 1966; Quantitative aspects of inhibition of virus replication by interferon in chick embryo cell cultures. Journal of Bacteriology 92:1047–1050
    [Google Scholar]
  8. Johnson R. G., Shendan J. D. 1971; Junction between cancer cells in culture: ultrastructure and permeability. Science, New York 174:717–719
    [Google Scholar]
  9. Kerr L. M. 1971; Protein synthesis in cell-free systems: an effect of interferon. Journal of Virology 7:448–459
    [Google Scholar]
  10. Koch A. L. 1964; The growth of viral plaques during the enlargement phase. Journal of Theoretical Biology 6:413–431
    [Google Scholar]
  11. Lwoff A. 1969; Death and transfiguration of a problem. Bacteriological Reviews 33:390–403
    [Google Scholar]
  12. Marcus P. I., Engelhardt D. L., Hunt J. M., Sekellick M. J. 1971; Interferon action: inhibition of vesicular stomatitis virus RNA synthesis induced by virion-bound polymerase. Science, New York 174:593–598
    [Google Scholar]
  13. Morahan P. S., Grossberg S. E. 1970; Age-related cellular resistance of the chicken embryo of viral infections. II. Inducible resistance produced by influenza virus and E. coli. Journal of Infectious Diseases 121:624–633
    [Google Scholar]
  14. Sheaff E. T., Stewart R. B. 1969; Interaction of interferon with cells: Induction of antiviral activity. Canadian Journal of Microbiology 15:941–953
    [Google Scholar]
  15. Takemoto K. D., Baron S. 1966; Non-heritable interferon resistance in a fraction of virus populations. Proceedings of the Society for Experimental Biology and Medicine 121:670–675
    [Google Scholar]
  16. Taylor J. 1964; Inhibition of interferon action by actinomycin. Biochemical and Biophysical Research Communications 14:447–451
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-20-2-139
Loading
/content/journal/jgv/10.1099/0022-1317-20-2-139
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error