The technique of frequency analysis of nearest neighbour base sequences in DNA (Josse, Kaiser & Kornberg, 1961) allows the characterization and description of a DNA in terms of the average frequency of occurrence of its sixteen possible doublet sequences. This technique has recently been used to study the patterns of doublet frequencies before and after normalization in the DNA of nine mammalian viruses (Subak-Sharpe, 1966; Morrison 1967; Subak-Sharpe, 1967). It was found that the doublet pattern in the DNA of the four small oncogenic viruses studied resembled the pattern in the host DNA to a remarkable extent, whereas the five large viruses investigated showed virtually no similarity to the host pattern.

The authors reasoned that a cell's translation apparatus, being the result of natural selection, would have a population of transfer RNAs adapted optimally to translate the polypeptide-specifying sequences of the cell DNA.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error