1887

Abstract

SUMMARY

Young adult CBA mice developed lethal infections with Coxsackie B-3 virus when immunosuppressed with cyclophosphamide. In the immunosuppressed mice high titres of virus and severe lesions were found in target organs, including the heart and pancreas, as well as persistent viraemia. Immunosuppressed animals showed transient production of IgM but no IgG virus neutralizing antibody; levels of interferon in peripheral blood were higher than in controls. Immunosuppressed mice could be passively protected by administration of serum antibody after infection. The results suggest that circulating antibody plays a critical role in limiting infection of young adult mice by Coxsackie B-3 virus.

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1973-06-01
2024-12-10
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References

  1. Allison A. C. 1972a; Immunity against viruses. The Scientific Basis of Medicine Annual Reviews49–73
    [Google Scholar]
  2. Allison A. C. 1972b; Immunity and immunopathology in virus infections. Annals Institute Pasteur 123:585–608
    [Google Scholar]
  3. Berry D. M., Almeida J. D. 1968; The morphological and biological effects of various antisera on avian infectious bronchitis virus. Journal of General Virology 3:97–102
    [Google Scholar]
  4. Brier A. M., Wahlenberg C. R., Notkins A. L. 1971; Immune injury of cells infected with herpes simplex virus (HSV). Federation Proceedings 30:353
    [Google Scholar]
  5. Cole G. A., Gilden D. H., Monjan A. A., Nathanson N. 1971; Lymphocytic choriomeningitis virus: pathogenesis of acute central nervous system disease. Federation Proceedings 30:1831–1841
    [Google Scholar]
  6. De Madrid A. T., Porterfield J. S. 1969; A simple micro-culture method for the study of group B arboviruses. Bulletin of World Health Organization 40:113–121
    [Google Scholar]
  7. Gatmaitan B. G., Chason J. L., Lerner M. 1970; Augmentation of the virulence of murine coxsackie virus B-3 myocardiopathy by exercise. Journal of Experimental Medicine 131:1121–1135
    [Google Scholar]
  8. Kilbourne E. D., Horsfall F. L. 1951; Lethal infection with coxsackie virus in adult mice given cortisone. proceedings of the Society for Experimental Biology and Medicine 77:135–138
    [Google Scholar]
  9. Makinodan T., Santos G. W., Quinn R. P. 1970; Immunosuppressive drugs. Pharmacological Reviews 22:189–247
    [Google Scholar]
  10. Mori R., Tasaki T., Kimura G., Takeya K. 1967; Depression of acquired resistance against herpes simplex virus infection in neonatally thymectomized mice. Archiv fur die Gesamte Virusforschung 21:459–462
    [Google Scholar]
  11. Murphy B. R., Glasgow L. A. 1968; Factors modifying host resistance to viral infection. III. Effect of whole body × irradiation on experimental encephalomyocarditis virus infection in mice. Journal of Experimental Medicine 27:1035–1052
    [Google Scholar]
  12. Petrov R. V., Manyko V. M., Khaitov R. M., Seslavina L. S. 1971; An experimental system for the simultaneous estimation of mitostatic and lymphotoxic effects of immunosuppressants and cytostatics. Journal of Experimental Medicine 133:640–648
    [Google Scholar]
  13. Rager-Zisman B., Allison A. C. 1973; The role of antibody and host cells in the resistance of mice against infection by coxsackie B-3 virus. Journal of General Virology 19:329–338
    [Google Scholar]
  14. Russell W. C. 1962; A sensitive and precise plaque assay for herpes virus. Nature, London 195:1028–1029
    [Google Scholar]
  15. Rytel M. W. 1969; Interferon response during coxsackie B-3 infection in mice. Journal of Infectious Diseases 120:379–382
    [Google Scholar]
  16. Santos G. W. 1967; Immunosuppressive drugs: I. Federation Proceedings 26:907–913
    [Google Scholar]
  17. Silverstein S. 1970; Macrophages and viral immunity. Seminars in Hematology 7:185–214
    [Google Scholar]
  18. Smith J. W., Adam E., Melnick J. L., Rawls W. E. 1972; Use of the 51Cr release test to demonstrate patterns of antibody response in humans to herpes virus types 1 and 2. Journal of Immunology 109:554–564
    [Google Scholar]
  19. Svehag S. E. 1968; Formation and dissociation of virus antibody complexes with special reference to the neutralization process. Progress in Medical Virology 10:1–63
    [Google Scholar]
  20. Turk J. L., Poulter L. W. 1972; Selective depletion of lymphoid tissue by cyclophosphamide. Clinical and Experimental Immunology 10:285–296
    [Google Scholar]
  21. Weiner P. W., Cole G. A., Nathanson N. 1971; Virus-specific immunologic depression in mice following combined immunization and cyclophosphamide-induced immunosuppression. Journal of Immunology 106:427–430
    [Google Scholar]
  22. Woodruff J. F., Kilbourne E. D. 1970; The influence of quantitated post weaning undemutrition on coxsackievirus B-3 infection of adult mice. I. Viral persistence and increased severity of lesions. Journal of Infectious Diseases 121:137–163
    [Google Scholar]
  23. Woodruff J. F., Woodruff J. J. 1971; Modification of severe Coxsackie virus B3 infection of marasmic mice by transfer of immune lymphoid cells. Proceedings of National Academy of Science of the United States of America 68:2108–2111
    [Google Scholar]
  24. Zisman B., Hirsch M. S., Allison A. C. 1970; Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. Journal of Immunology 104:1155–1159
    [Google Scholar]
  25. Zisman B., Wheelock E. F., Allison A. C. 1971; Role of macrophages and antibody in resistance of mice against yellow fever virus. Journal of Immunology 107:236–243
    [Google Scholar]
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